Peripheral biopterin and neopterin in schizophrenia and depression

Increasing evidence points to a causal involvement of inflammation in the pathogenesis neuropsychiatric disorders, including major depressive disorder (MDD) and schizophrenia (SZ). Neopterin biopterin may link peripheral immune system activation central neurotransmitter alterations. However, it is not fully established whether these alterations are transdiagnostic or disorder-specific they associated with reward-related psychopathologies. We investigated group differences neopterin plasma healthy comparison (HC) (n=19), SZ (n=45) MDD (n=43) participants. then correlated proteins CRP as measure for inflammation. Lastly, were psychopathological domain apathy. found trend-level difference levels no significant between groups. Within both patient groups, but HC, we show positive correlation biopterin. Further, observed correlations psychopathology SZ. While our study shows relevance future research, does support hypothesis that psychopathology.